Atp10a Gene Summary [Mouse]
Predicted to enable glycosylceramide flippase activity and phosphatidylcholine flippase activity. Predicted to be involved in phospholipid translocation and positive regulation of membrane tubulation. Predicted to be located in endoplasmic reticulum. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in plasma membrane. Is expressed in several structures, including adrenal gland; brain; dorsal grey horn; lung; and testis. Orthologous to human ATP10A (ATPase phospholipid transporting 10A (putative)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp10a |
| Official Name | ATPase, class V, type 10A [Source:MGI Symbol;Acc:MGI:1330809] |
| Ensembl ID | ENSMUSG00000025324 |
| Bio databases IDs | |
| Aliases | ATPase, class V, type 10A |
| Synonyms | ATP10C, ATPase, class V, type 10A, ATPase phospholipid transporting 10A (putative), ATPVA, ATPVC, LOC105376701, pfatp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp10a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- lipid transporter
- HAD-superfamily hydrolase, subfamily IIB
- phosphatidylcholine transporter
- phospholipid transporter
- phospholipid-translocating P-type ATPase, flippase
- sphingolipid transporter
- protein binding
- Cation transport ATPase (P-type)
- Haloacid Dehalogenase-like Hydrolases
- transporter
- Phospholipid-translocating P-type ATPase C-terminal
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- COVID-19
- weight gain
- cutaneous melanoma
- cutaneous melanoma cancer
- pervasive developmental disorder
- suicide
regulates
- cholesterol
- triacylglycerol
- fatty acid
- ion
- bile acid
role in cell
- tubulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- Endoplasmic Reticulum
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp10a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- phospholipid translocation
- ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- endoplasmic reticulum
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- magnesium ion binding
- ATPase activity
- ATP binding
- protein binding