Hnf1b Gene Summary [Mouse]
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and promoter-specific chromatin binding activity. Acts upstream of or within several processes, including negative regulation of mesenchymal cell apoptotic process; regulation of transcription by RNA polymerase II; and tube morphogenesis. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; gut; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; pancreas disease; renal cell carcinoma; renal cysts and diabetes syndrome; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hnf1b |
| Official Name | HNF1 homeobox B [Source:MGI Symbol;Acc:MGI:98505] |
| Ensembl ID | ENSMUSG00000020679 |
| Bio databases IDs | |
| Aliases | HNF1 homeobox B |
| Synonyms | ADTKD3, Eukaryotic transcription factor 2, FJHN, HNF-1-beta, HNF1beta (MODY5), HNF1 homeobox B, HNF-1-β, HNF2, Homeoprotein LFB3, HPC11, LF-B3, MODY5, RCAD, T2D, TCF-2, VHNF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnf1b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- dimerization domain
- nucleic acid binding
- transcription activation domain
- transcription factor binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- identical protein binding
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- binding protein
- Hepatocyte nuclear factor 1 (HNF-1), N terminus
- double-stranded DNA binding
- Hepatocyte nuclear factor 1 (HNF-1), beta isoform C terminus
- protein homodimerization
- POU specific domain
- homeodomain
- transcription factor activity
Pathways
Biological processes and signaling networks where the Hnf1b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- diffuse large B-cell lymphoma
- maturity-onset diabetes of the young type 5
- maturity-onset diabetes of the young
- prostate cancer
- polycystic kidney disease
- gastric carcinoma
- gastric epithelial cancer
- prostatic carcinoma
- epithelial cancer
role in cell
- proliferation
- expression in
- survival
- differentiation
- apoptosis
- cell death
- growth
- number
- activation in
- epithelial-mesenchymal transition by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- intracellular membrane-bounded organelle
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnf1b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- insulin secretion
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of mesenchymal stem cell apoptotic process involved in mesonephric nephron morphogenesis
- anterior/posterior pattern specification
- negative regulation of mesenchymal cell apoptotic process involved in metanephros development
- embryonic digestive tract morphogenesis
- pronephric nephron tubule development
- branching morphogenesis of a tube
- regulation of branch elongation involved in ureteric bud branching
- hepatoblast differentiation
- negative regulation of transcription from RNA polymerase II promoter
- response to glucose stimulus
- epithelial cell proliferation
- hindbrain development
- positive regulation of transcription, DNA-dependent
- kidney development
- inner cell mass cell differentiation
- pancreas development
- mesenchymal cell apoptotic process involved in metanephros development
- ureteric bud elongation
- mesonephric duct formation
- regulation of transcription from RNA polymerase II promoter
- pronephros development
- Notch signaling pathway
- positive regulation of gene expression
- endodermal cell fate specification
- regulation of Wnt receptor signaling pathway
- regulation of pronephros size
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- nucleus
- intracellular membrane-bounded organelle
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- identical protein binding
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity