Msx3 Gene Summary [Mouse]
Enables histone acetyltransferase binding activity and histone acetyltransferase regulator activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; future hindbrain; genitourinary system; and trunk mesenchyme. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Msx3 |
| Official Name | msh homeobox 3 [Source:MGI Symbol;Acc:MGI:106587] |
| Ensembl ID | ENSMUSG00000025469 |
| Bio databases IDs | |
| Aliases | msh homeobox 3 |
| Synonyms | HPX42B, msh homeobox 3, Msx3, NA88A, VENT homeobox, VENTX2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Msx3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- histone acetyltransferase regulator
- transcription regulator
- double-stranded DNA binding
- serine threonine rich domain
- protein binding
- sequence-specific DNA binding
- homeodomain
- proline rich domain
- histone acetyltransferase binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodegeneration
- experimental autoimmune encephalomyelitis
- androgenic alopecia
- demyelination
- chronic form of lymphocytic leukemia
role in cell
- expression in
- survival
- activation in
- proliferation
- binding in
- M1 polarization
- M2 polarization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Msx3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
- sequence-specific DNA binding RNA polymerase II transcription factor activity