Rbpms Gene Summary [Mouse]
Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in several processes, including SMAD protein signal transduction; regulation of alternative mRNA splicing, via spliceosome; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; gut; heart; retina; and urinary system. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbpms |
| Official Name | RNA binding protein gene with multiple splicing [Source:MGI Symbol;Acc:MGI:1334446] |
| Ensembl ID | ENSMUSG00000031586 |
| Bio databases IDs | |
| Aliases | RNA binding protein gene with multiple splicing |
| Synonyms | 2010300K22Rik, 2700019M19Rik, HERMES, LOC102723549, RGD1561067, RNA binding protein gene with multiple splicing, RNA binding protein, mRNA processing factor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbpms often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- mRNA 3' UTR binding
- transcription co-activator
- RNA recognition motif
- mRNA binding
- protein homodimerization
- protein binding
- identical protein binding
- RNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- uterine leiomyoma
- leiomyomatosis
- inguinal hernia
- myeloproliferative disorder
- oropharyngeal cancer
- cutaneous melanoma
- cutaneous melanoma cancer
- kidney carcinoma
- renal cancer
role in cell
- expression in
- proliferation
- production in
- alternative splicing by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbpms gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to oxidative stress
- macromolecular complex assembly
- positive regulation of transcription, DNA-dependent
- regulation of alternative nuclear mRNA splicing, via spliceosome
- SMAD protein signal transduction
- RNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasmic stress granule
- cytoplasm
- cytosol
- cytoplasmic mRNA processing body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- pre-mRNA intronic binding
- protein homodimerization activity
- RNA binding
- protein binding
- transcription coactivator activity
- mRNA binding
- mRNA 3'-UTR binding
- binding, bridging