Psmd13 Gene Summary [Mouse]
Predicted to enable endopeptidase activity and structural molecule activity. Acts upstream of or within meiosis I. Part of proteasome regulatory particle. Is expressed in diencephalon lateral wall ventricular layer; medulla oblongata alar plate ventricular layer; rest of cerebellum ventricular layer; telencephalon ventricular layer; and trunk mesenchyme. Orthologous to human PSMD13 (proteasome 26S subunit, non-ATPase 13). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Psmd13 |
| Official Name | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 [Source:MGI Symbol;Acc:MGI:1345192] |
| Ensembl ID | ENSMUSG00000025487 |
| Bio databases IDs | |
| Aliases | proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 |
| Synonyms | 26s Proteasome Rpn13, 26S Proteasome Subunit p40.5, HSPC027, p40.5, proteasome 26S subunit, non-ATPase 13, proteasome (prosome, macropain) 26S subunit, non-ATPase, 13, Rpn9, S11 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Psmd13 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase
- motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
- PCI domain
- ubiquitin binding domain
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Psmd13 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acute myeloid leukemia
- obesity
- uterine leiomyoma
- leiomyomatosis
- major depression
- endometriosis
- angina pectoris
- cerebral aneurysm
role in cell
- JQ1-sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- secretory granule lumen
- ficolin-1-rich granule lumen
- Extracellular Space
- Nucleus
- cytosol
- nucleoplasm
- clastosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Psmd13 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- meiosis I
- ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- membrane
- proteasome regulatory particle
- cytosol
- secretory granule lumen
- proteasome complex
- proteasome accessory complex
- proteasome regulatory particle, lid subcomplex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- structural molecule activity