Ifitm1

Involved in host-mediated suppression of symbiont invasion and response to virus. Acts upstream of or within defense response to virus and somitogenesis. Predicted to be located in early endosome and lysosomal membrane. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; embryo mesenchyme; extraembryonic component; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in COVID-19; adenosquamous gallbladder carcinoma; and gallbladder adenocarcinoma. Orthologous to human IFITM1 (interferon induced transmembrane protein 1) and IFITM3 (interferon induced transmembrane protein 3). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifitm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ifitm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.