Eif4a3 Gene Summary [Mouse]
Predicted to enable several functions, including ATP binding activity; RNA binding activity; and RNA helicase activity. Acts upstream of or within positive regulation of mRNA splicing, via spliceosome and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in submandibular gland primordium; telencephalon; testis; and vibrissa. Human ortholog(s) of this gene implicated in intellectual disability. Orthologous to human EIF4A3 (eukaryotic translation initiation factor 4A3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4a3 |
| Official Name | eukaryotic translation initiation factor 4A3 [Source:MGI Symbol;Acc:MGI:1923731] |
| Ensembl ID | ENSMUSG00000025580 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4A3 |
| Synonyms | 2400003O03Rik, DDX48, EIF4AIII, eukaryotic translation initiation factor 4A3, Fal1, hNMP265, mKIAA0111, MUK34, NMP265, NUK34, RCPS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4a3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- mRNA binding
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- ATP binding
- poly(A) binding protein
- enzyme
- protein binding
- Helicase conserved C-terminal domain
- RNA helicase
- RNA binding
- ribonucleoprotein binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Eif4a3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- organismal death
- glioblastoma
- glioblastoma cancer
- Richieri-Costa-Pereira syndrome
- prostate cancer
- psoriasis
- epileptic seizure
- nonalcoholic steatohepatitis
- chronic periodontal disease
role in cell
- proliferation
- expression in
- production in
- growth
- apoptosis
- migration
- cell cycle progression
- degradation in
- upregulation in
- processing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- glutaminergic synapse
- catalytic step 2 spliceosome
- Cytoplasm
- cytosol
- spliceosomes
- inner nuclear membrane
- nucleoplasm
- nucleoli
- interchromatin granule clusters
- perikaryon
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4a3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- exploration behavior
- positive regulation of translation
- embryonic cranial skeleton morphogenesis
- rRNA processing
- response to organic cyclic compound
- negative regulation of excitatory postsynaptic membrane potential
- associative learning
- nuclear mRNA splicing, via spliceosome
- mRNA export from nucleus
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
- cellular response to selenite ion
- negative regulation of translation
Cellular Component
Where in the cell the gene product is active
- exon-exon junction complex
- nuclear speck
- neuronal cell body
- nucleolus
- nucleoplasm
- dendrite
- nucleus
- catalytic step 2 spliceosome
- cytoplasm
- membrane
- U2-type catalytic step 1 spliceosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- ATP binding
- protein binding
- RNA binding
- RNA helicase activity
- poly(A) RNA binding
- ribonucleoprotein complex binding
- RNA stem-loop binding
- mRNA binding
- selenocysteine insertion sequence binding