Taf3 Gene Summary [Mouse]
Enables p53 binding activity and transcription regulator inhibitor activity. Involved in negative regulation of DNA-binding transcription factor activity and negative regulation of transcription by RNA polymerase II. Located in male germ cell nucleus. Is expressed in several structures, including eye; genitourinary system; heart; nervous system; and respiratory system. Orthologous to human TAF3 (TATA-box binding protein associated factor 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Taf3 |
| Official Name | TATA-box binding protein associated factor 3 [Source:MGI Symbol;Acc:MGI:2388097] |
| Ensembl ID | ENSMUSG00000025782 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor 3 |
| Synonyms | 4933439M23Rik, mTAFII140, TAF140, TAFII-140, TATA-box binding protein associated factor 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Taf3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone fold domain (HFD) superfamily
- PHD zinc finger
- transcription regulator
- protein binding activity, bridging
- PHD finger superfamily
- p53 binding
- protein binding
- Bromodomain associated
Pathways
Biological processes and signaling networks where the Taf3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- detergent resistant lipid raft fraction
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Taf3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mRNA transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- RNA polymerase II transcriptional preinitiation complex assembly
- positive regulation of transcription initiation from RNA polymerase II promoter
- negative regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of transcription from RNA polymerase II promoter
- maintenance of protein location in nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear membrane
- transcription factor TFIID complex
- nucleoplasm
- male germ cell nucleus
Molecular Function
What the gene product does at the molecular level
- p53 binding
- protein binding
- protein heterodimerization activity
- metal ion binding
- general RNA polymerase II transcription factor activity
- transcription factor binding