Kpna2

Enables DNA-binding transcription factor binding activity and nuclear import signal receptor activity. Involved in postsynapse to nucleus signaling pathway. Acts upstream of or within entry of viral genome into host nucleus through nuclear pore complex via importin; positive regulation of viral life cycle; and protein import into nucleus. Located in cytoplasmic stress granule. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human KPNA2 (karyopherin subunit alpha 2). [provided by Alliance of Genome Resources, Jul 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpna2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Kpna2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpna2 gene, providing context for its role in the cell.