Hmga2 Gene Summary [Mouse]
Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including endocrine system development; lung development; and positive regulation of cell population proliferation. Located in male germ cell nucleus and nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hmga2 |
| Official Name | high mobility group AT-hook 2 [Source:MGI Symbol;Acc:MGI:101761] |
| Ensembl ID | ENSMUSG00000056758 |
| Bio databases IDs | |
| Aliases | high mobility group AT-hook 2 |
| Synonyms | 9430083A20Rik, BABL, high mobility group AT-hook 2, HIGH MOBILITY GROUP protein I-C, HIGH MOBILITY GROUP protein isoform I-C, HMGI-C, LIPO, pg, pygmy, SRS5, STQTL9 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hmga2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- DNA binding domain
- nucleic acid binding
- transcription co-repressor
- DNA-(apurinic or apyrimidinic site) lyase
- enzyme binding
- DNA bending protein
- transcription factor binding
- chromatin binding
- protein domain specific binding
- enzyme
- protein binding
- sequence-specific DNA binding
- carbon-oxygen lyase
- acidic domain
- DNA binding
- AT DNA binding
- binding protein
- double-stranded DNA binding
- spacer domain
- AT hook domain
Pathways
Biological processes and signaling networks where the Hmga2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- non-insulin-dependent diabetes mellitus
- head and neck neoplasia
- rhabdomyosarcoma
- breast cancer
- Wilms tumor
- hepatoblastoma
- hepatocellular carcinoma
- neoplasia
- lung cancer
role in cell
- growth
- phosphorylation in
- expression in
- cellular infiltration by
- apoptosis
- survival
- proliferation
- quantity
- cell viability
- colony formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- heterochromatin
- Cytoplasm
- chromosome
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hmga2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation by host of viral transcription
- negative regulation of retroviral genome replication
- negative regulation of double-strand break repair via nonhomologous end joining
- base-excision repair
- chondrocyte differentiation
- mesodermal-endodermal cell signaling
- fat cell differentiation
- response to virus
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- positive regulation of angiogenesis
- negative regulation of transcription from RNA polymerase II promoter
- cell division
- negative regulation of DNA binding
- stem cell differentiation
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- mesenchymal cell differentiation
- regulation of stem cell maintenance
- intracellular signal transduction
- negative regulation of cellular senescence
- oncogene-induced senescence
- chromosome condensation
- regulation of transcription, DNA-dependent
- positive regulation of gene expression
- positive regulation of stem cell proliferation
- mesodermal cell differentiation
- heterochromatin assembly
- negative regulation of apoptotic process
- positive regulation of cell proliferation in bone marrow
- endodermal cell differentiation
- chondrocyte proliferation
- epithelial to mesenchymal transition
- positive regulation of protein serine/threonine kinase activity
- regulation of cell cycle process
Cellular Component
Where in the cell the gene product is active
- SMAD protein complex
- nucleus
- protein-DNA complex
- nuclear chromosome
- senescence-associated heterochromatin focus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- cAMP response element binding
- nucleosomal DNA binding
- DNA binding, bending
- AT DNA binding
- transcription regulatory region sequence-specific DNA binding
- nucleic acid binding
- transcription cofactor activity
- 5'-deoxyribose-5-phosphate lyase activity
- protein binding
- SMAD binding
- transcription corepressor activity
- C2H2 zinc finger domain binding
- DNA-(apurinic or apyrimidinic site) lyase activity
- MH2 domain binding
- MH1 domain binding