Tmem14a Gene Summary [Mouse]
Predicted to be involved in negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway and regulation of heme biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in mitochondrial membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human TMEM14A (transmembrane protein 14A). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tmem14a |
| Official Name | transmembrane protein 14A [Source:MGI Symbol;Acc:MGI:1922962] |
| Ensembl ID | ENSMUSG00000025933 |
| Bio databases IDs | |
| Aliases | transmembrane protein 14A |
| Synonyms | 5730496E24RIK, C6orf73, LOC103693210, PTD011, transmembrane protein 14A |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tmem14a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Transmembrane proteins 14C
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- endoplasmic reticulum membrane
- mitochondrial membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tmem14a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of heme biosynthetic process
- negative regulation of apoptotic process
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- mitochondrial membrane
Molecular Function
What the gene product does at the molecular level
- protein binding