Hnrnpk Gene Summary [Mouse]

The protein encoded by this gene is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complex, and is a poly-cytosine binding protein (PCBP). It is found in multiple subcellular compartments including the nucleus, cytoplasm and mitochondria. This gene product is thought to interact with RNA, DNA, and protein, and is involved in multiple cellular processes, including transcription, chromatin remodeling, DNA damage response, signal transduction, mRNA splicing, export, and translation. Multiple transcript variants and protein isoforms exist, with some isoforms containing a unique C-terminus. There are four pseudogenes of this gene, found on chromosomes 2, 3, 7 and 13. [provided by RefSeq, Aug 2014]

Details

Type
Protein Coding
Official Symbol
Hnrnpk
Official Name
heterogeneous nuclear ribonucleoprotein K [Source:MGI Symbol;Acc:MGI:99894]
Ensembl ID
ENSMUSG00000021546
Bio databases IDs NCBI: 15387 Ensembl: ENSMUSG00000021546
Aliases heterogeneous nuclear ribonucleoprotein K
Synonyms AUKS, CSBP, heterogeneous nuclear ribonucleoprotein K, HNRPK, KBBP, NOVA, TUNP
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hnrnpk often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • RGG domain
  • nucleic acid binding
  • mRNA binding
  • actinin binding
  • heat shock protein binding
  • lamin binding
  • HCV core protein binding domain
  • protein domain specific binding
  • K homology RNA-binding domain
  • protein binding
  • sequence-specific DNA binding
  • proline rich domain
  • identical protein binding
  • RNA binding
  • ATPase binding
  • mRNA 3' UTR binding
  • KH domain
  • single-stranded DNA binding
  • K homology (KH) RNA-binding domain, type I
  • ROKNT (NUC014) domain
  • double-stranded DNA binding
  • pre-mRNA 3' splice site binding
  • ribonucleoprotein binding

Pathways

Biological processes and signaling networks where the Hnrnpk gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • ulcerative colitis
  • mental retardation
  • epithelial cancer
  • tumorigenesis
  • Au-Kline syndrome
  • hepatitis B virus-related hepatocellular carcinoma
  • liver cancer
  • hereditary disorder
  • mucoepidermoid carcinoma
  • melanoma
regulated by
regulates
role in cell
  • activation in
  • apoptosis
  • expression in
  • binding in
  • phosphorylation in
  • proliferation
  • production in
  • differentiation
  • invasion by
  • migration

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nuclear fraction
  • soluble fraction
  • glutaminergic synapse
  • catalytic step 2 spliceosome
  • Cytoplasm
  • postsynaptic region
  • inner membrane
  • cell cortex
  • Mitochondria
  • cytosol
  • nucleoplasm
  • nucleoli
  • interchromatin granule clusters
  • dendritic spines
  • mitoplasts
  • stress granule
  • chromatin
  • axon terminals
  • paraspeckle-like structures
  • cytoplasmic fraction
  • cytosolic fraction

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Hnrnpk gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • negative regulation of transcription, DNA-dependent
  • regulation of low-density lipoprotein particle clearance
  • signal transduction
  • negative regulation of nuclear mRNA splicing, via spliceosome
  • negative regulation of apoptotic process
  • regulation of nuclear mRNA splicing, via spliceosome
  • RNA processing
  • positive regulation of transcription from RNA polymerase II promoter
  • positive regulation of receptor-mediated endocytosis
  • nuclear mRNA splicing, via spliceosome
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • cytoplasmic stress granule
  • extracellular vesicular exosome
  • focal adhesion
  • catalytic step 2 spliceosome
  • cytoplasm
  • membrane
  • chromatin
  • cell projection
  • podosome
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • DNA binding
  • protein domain specific binding
  • identical protein binding
  • protein binding
  • RNA binding
  • cadherin binding
  • mRNA binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.