Kpnb1 Gene Summary [Mouse]
Enables Hsp90 protein binding activity; importin-alpha family protein binding activity; and nuclear import signal receptor activity. Acts upstream of or within ribosomal protein import into nucleus. Located in cytoplasmic stress granule. Part of protein-containing complex. Is expressed in several structures, including gonad; metencephalon alar plate; neural retina; pancreas; and telencephalon. Orthologous to human KPNB1 (karyopherin subunit beta 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Kpnb1 |
| Official Name | karyopherin (importin) beta 1 [Source:MGI Symbol;Acc:MGI:107532] |
| Ensembl ID | ENSMUSG00000001440 |
| Bio databases IDs | |
| Aliases | karyopherin (importin) beta 1 |
| Synonyms | IMB1, Imp beta 1, Impnb, IMPORTIN 90, Importin Beta 1, Importin β, Importin β 1, Imp β 1, IPO1, IPOB, karyopherin subunit beta 1, karyopherin subunit β 1, Karyopherin β 1, NTF97, Nuclear factor P97, p97, Ptac97 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kpnb1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HEAT repeat
- binding protein
- HEAT-like repeat
- zinc ion binding
- heat shock protein binding
- enzyme binding
- protein domain specific binding
- Importin-beta N-terminal domain
- protein binding
- nuclear localization sequence binding
- kinesin binding
- Ran binding domain
Pathways
Biological processes and signaling networks where the Kpnb1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- melanoma
- melanoma cancer
- metastasis
- neoplasia
- organismal death
- myopathy
- psoriasis
- spinocerebellar ataxia type 3
- mucopolysaccharidosis type IVB
- NPM1 mutation positive acute myeloid leukemia
role in cell
- accumulation in
- expression in
- phosphorylation in
- apoptosis
- migration
- invasion by
- colony formation
- binding
- proliferation
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- interchromatin granule cluster fractions
- detergent resistant lipid raft fraction
- endoplasmic reticulum tubules
- secretory granule lumen
- ficolin-1-rich granule lumen
- Cytoplasm
- Extracellular Space
- perinuclear region
- Mitochondria
- cytosol
- nuclear pores
- inner nuclear membrane
- nucleoplasm
- nuclear envelope
- stress granule
- perikaryon
- detergent-soluble fraction
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kpnb1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- astral microtubule organization
- RNA import into nucleus
- establishment of mitotic spindle localization
- protein import into nucleus
- NLS-bearing substrate import into nucleus
- mitotic chromosome movement towards spindle pole
- mitotic metaphase plate congression
- spindle assembly involved in mitosis
- ribosomal protein import into nucleus
Cellular Component
Where in the cell the gene product is active
- cytoplasmic stress granule
- specific granule lumen
- NLS-dependent protein nuclear import complex
- extracellular region
- nuclear pore
- nucleoplasm
- nuclear envelope
- nucleus
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- membrane
- endoplasmic reticulum tubular network
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- protein domain specific binding
- RNA binding
- protein binding
- small GTPase binding
- Hsp90 protein binding
- nuclear localization sequence binding
- enzyme binding