Ranbp2

Enables SUMO transferase activity and kinase activator activity. Involved in nuclear export. Acts upstream of or within intracellular glucose homeostasis and regulation of gluconeogenesis. Predicted to be located in annulate lamellae; cytoplasmic periphery of the nuclear pore complex; and nucleus. Predicted to be part of SUMO ligase complex; nuclear pore cytoplasmic filaments; and nuclear pore nuclear basket. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; eye; genitourinary system; hemolymphoid system; and nervous system. Human ortholog(s) of this gene implicated in brain disease and inflammatory myofibroblastic tumor. Orthologous to human RANBP2 (RAN binding protein 2). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ranbp2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Ranbp2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.

Describes the biological processes, cellular components, and molecular functions associated with the mouse Ranbp2 gene, providing context for its role in the cell.