Ecrg4 Gene Summary [Mouse]
Predicted to enable neuropeptide hormone activity. Acts upstream of or within G1 to G0 transition; anaphase-promoting complex-dependent catabolic process; and cellular senescence. Located in extracellular space. Is expressed in several structures, including adrenal gland; central nervous system; heart; skeleton; and urinary system. Orthologous to human ECRG4 (ECRG4 augurin precursor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ecrg4 |
| Official Name | ECRG4 augurin precursor [Source:MGI Symbol;Acc:MGI:1926146] |
| Ensembl ID | ENSMUSG00000026051 |
| Bio databases IDs | |
| Aliases | ECRG4 augurin precursor |
| Synonyms | 1500015O10Rik, C2orf40, ECRG4 augurin precursor, RGD1305645, Similar to gadd45 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ecrg4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- neuropeptide hormone
- Oesophageal cancer-related gene 4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- osteoarthritis
- breast cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- HER2 negative hormone receptor negative breast cancer
- Huntington disease
- hip osteoarthritis
- esophageal carcinoma
- esophageal carcinoma formation
role in cell
- degradation in
- proliferation
- senescence
- senescence in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- apical membrane
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ecrg4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- cellular senescence
- anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
- G1 to G0 transition
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytoplasm
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding