Avp Gene Summary [Mouse]
This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin binds to vasopressin receptors and functions as a vasopressor, to constrict blood vessels and increase blood pressure, and as an antidiuretic, to reduce the production of urine. Neurophysin 2 functions as a carrier protein in the transport of arginine vasopressin. This gene is present in a gene cluster with the related gene oxytocin on chromosome 2. [provided by RefSeq, Aug 2015]
Details
| Type | Protein Coding |
| Official Symbol | Avp |
| Official Name | arginine vasopressin [Source:MGI Symbol;Acc:MGI:88121] |
| Ensembl ID | ENSMUSG00000037727 |
| Bio databases IDs | |
| Aliases | arginine vasopressin |
| Synonyms | ADH, ARG8 VASOPRESSIN, arginine vasopressin, ARVP, AVP-NPII, AVRP, DI, NEUROPHYSIN II, prepro-argenine vasopressin-neurophysin 2-copeptin, Vas, VP, Vsp |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Avp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Neurohypophysial hormones, C-terminal Domain
- G-protein-coupled receptor binding
- caspase inhibitor activity
- signal peptide
- neurophysin domain
- protein binding
- receptor binding
- neuropeptide hormone
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- proteinuria
- neurohypophyseal diabetes insipidus
- major depression
- community acquired pneumonia
- bradycardia
- glomerular endotheliosis
- septic shock
- catalepsy
- diabetes insipidus
role in cell
- apoptosis
- expression in
- production in
- proliferation
- phosphorylation in
- activation in
- cell viability
- accumulation in
- cell cycle progression
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- plasma membrane fraction
- membrane fraction
- endocytic vesicle membrane
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- granules
- cytosol
- plasma membrane projections
- neurites
- nerve ending
- dense-core vesicles
- cytoplasmic vesicles
- secretory granules
- perikaryon
- axons
- dendrites
- axon terminals
- plasma
- Herring bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Avp gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- viral entry into host cell
- protein kinase C signaling cascade
- positive regulation of vasoconstriction
- positive regulation of cell proliferation
- vasoconstriction
- maternal behavior
- response to ethanol
- water transport
- positive regulation of cell growth
- grooming behavior
- locomotory behavior
- multicellular organismal water homeostasis
- positive regulation of cellular pH reduction
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
- response to testosterone stimulus
- positive regulation of peptidyl-serine phosphorylation
- social behavior
- generation of precursor metabolites and energy
- positive regulation of prostaglandin biosynthetic process
- negative regulation of release of cytochrome c from mitochondria
- signal transduction
- positive regulation of systemic arterial blood pressure
- cell-cell signaling
- response to nicotine
- negative regulation of female receptivity
- elevation of cytosolic calcium ion concentration
- ERK1 and ERK2 cascade
- maternal aggressive behavior
- negative regulation of transmission of nerve impulse
- positive regulation of gene expression
- negative regulation of apoptotic process
- positive regulation of glutamate secretion
Cellular Component
Where in the cell the gene product is active
- dendrite
- extracellular space
- clathrin-coated endocytic vesicle membrane
- secretory granule
- cytosol
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- neurohypophyseal hormone activity
- neuropeptide hormone activity
- V1A vasopressin receptor binding
- protein kinase activity
- receptor binding
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process
- V1B vasopressin receptor binding