Coa5 Gene Summary [Mouse]
Acts upstream of or within leukocyte differentiation; spleen development; and thymus development. Located in mitochondrion. Is expressed in cerebral cortex; heart ventricle; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in mitochondrial complex IV deficiency nuclear type 9. Orthologous to human COA5 (cytochrome c oxidase assembly factor 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Coa5 |
| Official Name | cytochrome C oxidase assembly factor 5 [Source:MGI Symbol;Acc:MGI:1923428] |
| Ensembl ID | ENSMUSG00000026112 |
| Bio databases IDs | |
| Aliases | cytochrome C oxidase assembly factor 5 |
| Synonyms | 1700001A24Rik, 6330578E17Rik, C2orf64, CEMCOX3, cytochrome C oxidase assembly factor 5, MC4DN9, Pet191, RGD1565095 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Coa5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cytochrome c oxidase assembly protein PET191
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Coa5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial respiratory chain complex IV assembly
Cellular Component
Where in the cell the gene product is active
- mitochondrion
Molecular Function
What the gene product does at the molecular level
- protein binding