Casp14 Gene Summary [Mouse]
Predicted to enable peptidase activity. Predicted to be involved in positive regulation of neuron apoptotic process. Predicted to act upstream of or within proteolysis. Is active in cornified envelope. Is expressed in several structures, including autopod and skin. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis. Orthologous to human CASP14 (caspase 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Casp14 |
| Official Name | caspase 14 [Source:MGI Symbol;Acc:MGI:1335092] |
| Ensembl ID | ENSMUSG00000005355 |
| Bio databases IDs | |
| Aliases | caspase 14 |
| Synonyms | ARCI12, caspase-14, Caspase-14a, MICE, mini-ICE |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Casp14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- CASc
- cysteine endopeptidase
- peptidase
- protein binding
Pathways
Biological processes and signaling networks where the Casp14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- autosomal recessive congenital ichthyosis type 12
role in cell
- expression in
- apoptosis
- activation in
- binding in
- co-activation in
- acetylation in
- cell-cell fusion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- Nucleus
- Mitochondria
- cytosol
- nucleoplasm
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Casp14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- epidermis development
- cornification
- keratinization
- positive regulation of neuron apoptotic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cornified envelope
- keratin filament
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cysteine-type endopeptidase activity