Plekhb2 Gene Summary [Mouse]
Predicted to enable phosphatidylinositol-3,4,5-trisphosphate binding activity. Predicted to be involved in regulation of cell differentiation. Predicted to be located in recycling endosome membrane. Predicted to be active in membrane. Is expressed in gut. Orthologous to human PLEKHB2 (pleckstrin homology domain containing B2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Plekhb2 |
| Official Name | pleckstrin homology domain containing, family B (evectins) member 2 [Source:MGI Symbol;Acc:MGI:2385825] |
| Ensembl ID | ENSMUSG00000026123 |
| Bio databases IDs | |
| Aliases | pleckstrin homology domain containing, family B (evectins) member 2 |
| Synonyms | 2310009M15Rik, DKFZP762F2110, Evectin-2, Evection-2, EVT2, Phdc, pleckstrin homology domain containing B2, pleckstrin homology domain containing, family B (evectins) member 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Plekhb2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- phosphatidylinositol-3,4,5-triphosphate binding
- PH domain
- protein binding
- Pleckstrin homology-like domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Plekhb2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell differentiation
Cellular Component
Where in the cell the gene product is active
- membrane
- recycling endosome membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-3,4,5-trisphosphate binding
- protein binding