Gga3 Gene Summary [Mouse]
Predicted to enable protein transporter activity; small GTPase binding activity; and ubiquitin binding activity. Acts upstream of or within positive regulation of protein catabolic process and protein localization to lysosome. Predicted to be located in Golgi apparatus; endosome; and lysosome. Predicted to be part of protein-containing complex. Predicted to be active in trans-Golgi network. Is expressed in several structures, including heart; liver; lung; metanephros; and white fat. Orthologous to human GGA3 (golgi associated, gamma adaptin ear containing, ARF binding protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gga3 |
| Official Name | golgi associated, gamma adaptin ear containing, ARF binding protein 3 [Source:MGI Symbol;Acc:MGI:2384159] |
| Ensembl ID | ENSMUSG00000020740 |
| Bio databases IDs | |
| Aliases | golgi associated, gamma adaptin ear containing, ARF binding protein 3 |
| Synonyms | C230037M19Rik, golgi associated, gamma adaptin ear containing, ARF binding protein 3, golgi associated, γ adaptin ear containing, ARF binding protein 3, golgi localizing, γ adaptin ear homology domain, arf binding protein 3, mKIAA0154 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gga3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GAT_SF
- N-terminal extension of GAT domain
- GAE domain
- Adaptin C-terminal domain
- enzyme binding
- ubiquitin binding
- protein binding
- proline rich domain
- Domain present in VPS-27, Hrs and STAM
- binding protein
- ear domain
- GGA homology domain
- hinge domain
- VHS, ENTH and ANTH domain superfamily
- GAT domain
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Alzheimer disease
role in cell
- morphology
- binding in
- catabolism by
- accumulation in
- degradation in
- sorting in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- cellular membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- trans Golgi network
- endosomal membrane
- recycling endosomes
- early endosomes
- clathrin-coated vesicles
- cytoplasmic fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gga3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein localization at cell surface
- protein destabilization
- regulation of protein stability
- protein catabolic process
- Golgi to plasma membrane transport
- Golgi to plasma membrane protein transport
- protein targeting to lysosome
- intracellular protein transport
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- trans-Golgi network
- endosome membrane
- Golgi apparatus
- macromolecular complex
- recycling endosome membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin binding
- phosphatidylinositol binding
- small GTPase binding