Dazap2 Gene Summary [Mouse]
Enables mitogen-activated protein kinase kinase kinase binding activity; protein serine/threonine kinase activator activity; and receptor tyrosine kinase binding activity. Predicted to be involved in protein destabilization and stress granule assembly. Predicted to be located in cytoplasmic stress granule and nuclear speck. Predicted to be part of protein-containing complex. Is expressed in several structures, including brain ventricular layer; genitourinary system; jaw; liver; and sensory organ. Orthologous to human DAZAP2 (DAZ associated protein 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dazap2 |
| Official Name | DAZ associated protein 2 [Source:MGI Symbol;Acc:MGI:1344344] |
| Ensembl ID | ENSMUSG00000000346 |
| Bio databases IDs | |
| Aliases | DAZ associated protein 2 |
| Synonyms | Brbp, DAZ associated protein 2, GCAP28, gt6-12, mKIAA0058, PRTB |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dazap2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- ubiquitin protein ligase binding
- protein kinase binding
- receptor tyrosine kinase binding
- PPXY motif
- WW domain binding
- transcription factor binding
- p53 binding
- protein binding
- identical protein binding
- DAZ associated protein 2 (DAZAP2)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- eosinophilia
- severe acute respiratory syndrome
- infection by HIV-1
role in cell
- activation in
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- nuclear bodies
- nuclear speckles
- stress granule
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dazap2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein destabilization
- stress granule assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasmic stress granule
- cytoplasm
- nuclear speck
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- p53 binding
- ubiquitin protein ligase binding
- protein serine/threonine kinase activator activity
- protein binding
- mitogen-activated protein kinase kinase kinase binding
- receptor tyrosine kinase binding
- WW domain binding