Slc11a1 Gene Summary [Mouse]
Enables iron ion transmembrane transporter activity; manganese ion transmembrane transporter activity; and metal cation:proton antiporter activity. Involved in iron ion transport and manganese ion transport. Acts upstream of or within several processes, including defense response to other organism; intracellular monoatomic cation homeostasis; and positive regulation of macromolecule metabolic process. Located in late endosome membrane; lysosomal membrane; and phagocytic vesicle membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in several diseases, including Buruli ulcer disease; autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slc11a1 |
| Official Name | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 [Source:MGI Symbol;Acc:MGI:1345275] |
| Ensembl ID | ENSMUSG00000026177 |
| Bio databases IDs | |
| Aliases | solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
| Synonyms | Bcg, Itg, Ity, Ity1, LSH, NRAMP, NRAMP1, solute carrier family 11 member 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc11a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen ion transporter
- manganese ion transporter
- antiporter
- protein homodimerization
- iron ion transporter
- Natural resistance-associated macrophage protein
- transition metal ion transporter
- Solute carrier families 5 and 6-like; solute binding domain
- metal ion transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc11a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- breast adenocarcinoma
- Alzheimer disease
- tuberculosis
- autoimmune disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- susceptibility to buruli ulcer
- susceptibility to tuberculosis
- experimentally-induced arthritis
role in cell
- expression in
- production in
- survival
- activation in
- growth
- formation in
- activity
- acidification
- activation
- recruitment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- intracellular space
- cellular membrane
- lysosome
- secretory granule membrane
- granules
- tertiary granule membrane
- lysosome membrane
- lysosomal compartment
- endosomal membrane
- late endosomes
- tertiary granules
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc11a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- multicellular organismal iron ion homeostasis
- vacuolar acidification
- positive regulation of transcription from RNA polymerase II promoter
- macrophage activation
- defense response to protozoan
- cellular iron ion homeostasis
- inflammatory response
- wound healing
- nitrite transport
- antigen processing and presentation of peptide antigen
- positive regulation of interferon-gamma production
- activation of protein kinase activity
- metal ion transport
- establishment of localization in cell
- defense response to Gram-negative bacterium
- response to interferon-gamma
- cell redox homeostasis
- respiratory burst
- defense response to bacterium
- response to bacterium
- MHC class II biosynthetic process
- manganese ion transport
- manganese ion transmembrane transport
- cadmium ion transmembrane transport
- iron ion transport
- positive regulation of gene expression
- mRNA stabilization
- phagocytosis
- T cell proliferation involved in immune response
- positive regulation of dendritic cell antigen processing and presentation
- positive regulation of T-helper 1 type immune response
- response to lipopolysaccharide
- antimicrobial humoral response
- positive regulation of phagocytosis
- negative regulation of cytokine production
- positive regulation of cytokine production
- iron ion transmembrane transport
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- late endosome
- phagocytic vesicle membrane
- endosome membrane
- plasma membrane
- tertiary granule membrane
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- transition metal ion transmembrane transporter activity
- protein homodimerization activity
- iron ion transmembrane transporter activity
- cadmium ion transmembrane transporter activity
- manganese ion transmembrane transporter activity
- metal ion:hydrogen antiporter activity