Chrng Gene Summary [Mouse]
Enables acetylcholine-gated monoatomic cation-selective channel activity. Acts upstream of or within regulation of membrane potential. Located in postsynaptic membrane. Part of acetylcholine-gated channel complex. Is expressed in several structures, including diaphragm; face; limb bud; rib cartilage condensation; and skeletal musculature. Human ortholog(s) of this gene implicated in contractures, pterygia, and spondylocarpotarsal fusion syndrome. Orthologous to human CHRNG (cholinergic receptor nicotinic gamma subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Chrng |
| Official Name | cholinergic receptor, nicotinic, gamma polypeptide [Source:MGI Symbol;Acc:MGI:87895] |
| Ensembl ID | ENSMUSG00000026253 |
| Bio databases IDs | |
| Aliases | cholinergic receptor, nicotinic, gamma polypeptide |
| Synonyms | Achr-3, ACHRG, Acrg, cholinergic receptor, nicotinic, gamma polypeptide, cholinergic receptor nicotinic gamma subunit, cholinergic receptor, nicotinic, γ polypeptide, cholinergic receptor nicotinic γ subunit, NACHR gamma, NACHR γ |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chrng often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- excitatory extracellular ligand-gated ion channel
- channel/pore class transporter
- extracellular ligand-gated ion channel
- Cation transporter family protein
- protein binding
- acetylcholine receptor
- neurotransmitter receptor
- LGIC_ECD
- Neurotransmitter-gated ion-channel transmembrane region
- Neurotransmitter-gated ion-channel ligand binding domain
- ligand-gated ion channel
- transmembrane receptor
- cation channel
Pathways
Biological processes and signaling networks where the Chrng gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- MDFI
- KRTAP5-9
- NOTCH2NLA/NOTCH2NLB
- pancuronium
- doxacurium
- atracurium
- mivacurium
- arecoline
- mecamylamine
- vecuronium
disease
- Alzheimer disease
- major depression
- traumatic brain injury
- schizophrenia
- bladder cancer
- critical illness
- escobar syndrome
- hereditary disorder
- peripheral neuropathy
- postoperative pain
regulates
- cation
role in cell
- abnormal morphology
- transmembrane potential
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- postsynaptic membrane
- motor endplates
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chrng gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission, cholinergic
- regulation of excitatory postsynaptic membrane potential
- signal transduction
- muscle contraction
- ion transmembrane transport
- synaptic transmission
- membrane depolarization
Cellular Component
Where in the cell the gene product is active
- postsynaptic membrane
- acetylcholine-gated channel complex
- synapse
- neuron projection
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- channel activity
- protein binding
- acetylcholine receptor activity
- acetylcholine-gated cation channel activity