Camk2g Gene Summary [Mouse]

Enables calcium/calmodulin-dependent protein kinase activity. Involved in regulation of neuron projection development and regulation of relaxation of cardiac muscle. Acts upstream of or within G1/S transition of mitotic cell cycle; calcium ion transport; and protein autophosphorylation. Located in postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 59. Orthologous to human CAMK2G (calcium/calmodulin dependent protein kinase II gamma). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Camk2g
Official Name
calcium/calmodulin-dependent protein kinase II gamma [Source:MGI Symbol;Acc:MGI:88259]
Ensembl ID
ENSMUSG00000021820
Bio databases IDs NCBI: 12325 Ensembl: ENSMUSG00000021820
Aliases calcium/calmodulin-dependent protein kinase II gamma
Synonyms calcium/calmodulin-dependent protein kinase II gamma, calcium/calmodulin-dependent protein kinase II γ, CAMK, CAMK2G B, CAMKG, CAMK-II, Camkii gamma, Camkii γ, CaM kinase II γ, LOC100909586, MRD59
Species
Mouse, Mus musculus
OrthologiesHumanRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Camk2g often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • protein serine/threonine kinase
  • Protein kinase (unclassified specificity)
  • Protein tyrosine and serine/threonine kinase
  • SnoaL-like domain
  • protein binding
  • Protein kinase domain
  • identical protein binding
  • calmodulin regulated protein kinase
  • kinase
  • Serine/Threonine protein kinases, catalytic domain
  • Protein Kinases, catalytic domain
  • protein homodimerization
  • NTF2_like
  • Tyrosine kinase, catalytic domain

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • neoplasia
  • interstitial fibrosis
  • liver cancer
  • autosomal dominant intellectual developmental disorder type 59
  • pervasive developmental disorder
  • left ventricular dysfunction
  • psoriasis
  • cardiac hypertrophy
  • asthma
  • chronic obstructive pulmonary disease
regulated by
regulates
role in cell
  • apoptosis
  • activation in
  • cell death
  • phosphorylation in
  • proliferation
  • synthesis in
  • survival
  • expression in
  • quantity
  • binding in

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • glutaminergic synapse
  • endocytic vesicle membrane
  • Nucleus
  • cytosol
  • nucleoplasm
  • sarcoplasmic reticulum membrane
  • postsynaptic density

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the mouse Camk2g gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • insulin secretion
  • cell differentiation
  • nervous system development
  • regulation of neuron projection development
  • regulation of calcium ion transport
  • regulation of skeletal muscle adaptation

Cellular Component

Where in the cell the gene product is active
  • calcium- and calmodulin-dependent protein kinase complex
  • cytoplasm
  • membrane
  • cytosol
  • neuron projection
  • endocytic vesicle membrane
  • sarcoplasmic reticulum membrane
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • ATP binding
  • calmodulin binding
  • identical protein binding
  • protein homodimerization activity
  • protein binding
  • calcium-dependent protein serine/threonine phosphatase activity
  • calmodulin-dependent protein kinase activity

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.