C4bp Gene Summary [Mouse]

Predicted to be involved in several processes, including negative regulation of complement activation, classical pathway; regulation of opsonization; and response to symbiotic bacterium. Predicted to be located in extracellular region. Predicted to be active in extracellular space and plasma membrane. Is expressed in foregut-midgut junction; midgut; midgut loop; renal calyx; and renal pelvis. Human ortholog(s) of this gene implicated in COVID-19. Orthologous to human C4BPA (complement component 4 binding protein alpha). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
C4bp
Official Name
complement component 4 binding protein [Source:MGI Symbol;Acc:MGI:88229]
Ensembl ID
ENSMUSG00000026405
Bio databases IDs NCBI: 12269 Ensembl: ENSMUSG00000026405
Aliases complement component 4 binding protein
Synonyms AI195242, C4bpa, C4bp α, complement component 4 binding protein
Species
Mouse, Mus musculus

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse C4bp often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • CCP
  • protein binding
  • Sushi repeat (SCR repeat)
  • SUSHI repeat
  • Oligomerization domain of C4b-binding protein alpha

Pathways

Biological processes and signaling networks where the C4bp gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
disease
  • Staphylococcus aureus pneumonia
regulated by
  • diethylnitrosamine
  • Collagen(s)
  • AGT
  • dexamethasone
  • ciprofibrate
  • hydrogen peroxide
  • ACOX1
  • PROS1
  • TO-901317
role in cell
  • apoptosis
  • activation in
  • production in
  • influx

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

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