Pros1 Gene Summary [Mouse]
This gene encodes a vitamin K-dependent protein with key roles in multiple biological processes including coagulation, apoptosis and vasculogenesis. The encoded protein undergoes proteolytic processing to generate a mature protein which is secreted into the plasma. Mice lacking the encoded protein die in utero from a fulminant coagulopathy and associated hemorrhages. [provided by RefSeq, Oct 2015]
Details
| Type | Protein Coding |
| Official Symbol | Pros1 |
| Official Name | protein S (alpha) [Source:MGI Symbol;Acc:MGI:1095733] |
| Ensembl ID | ENSMUSG00000022912 |
| Bio databases IDs | |
| Aliases | protein S (alpha) |
| Synonyms | PROS, PROSP, Protein S, protein S (alpha), protein S (α), PS21, PS22, PS23, PS24, PS25, PSA, S-protein, THPH5, THPH6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pros1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- Complement Clr-like EGF-like
- binding protein
- LamG
- globular domain
- protein binding
- EGF-like domain
- laminin-type G domain 4 module
- Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain
- Coagulation Factor Xa inhibitory site
- laminin G domain
- EGF_CA
Pathways
Biological processes and signaling networks where the Pros1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colitis
- autosomal recessive thrombophilia due to protein S deficiency
- autosomal dominant thrombophilia due to protein S deficiency
- venous thrombosis
- septic shock
- hemarthrosis
- protein S deficiency
- Alzheimer disease
- hypoplasia
- essential thrombocythemia
role in cell
- apoptosis
- survival
- cell death
- expression in
- phosphorylation in
- binding
- number
- proliferation
- migration
- engulfment
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi lumen
- Cytoplasm
- perinuclear region
- Plasma Membrane
- endoplasmic reticulum membrane
- Golgi membrane
- alpha granules
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pros1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- blood coagulation
- fibrinolysis
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- platelet alpha granule lumen
- extracellular space
- extracellular vesicular exosome
- blood microparticle
- Golgi membrane
- extracellular region
- Golgi lumen
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- endopeptidase inhibitor activity
- calcium ion binding