Rbbp5 Gene Summary [Mouse]
Predicted to enable histone binding activity and transcription cis-regulatory region binding activity. Predicted to be involved in response to estrogen and transcription initiation-coupled chromatin remodeling. Predicted to act upstream of or within DNA damage response. Predicted to be located in nucleolus and nucleoplasm. Predicted to be part of MLL1 complex; MLL3/4 complex; and Set1C/COMPASS complex. Is expressed in cerebral cortex and genitourinary system. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rbbp5 |
| Official Name | retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit [Source:MGI Symbol;Acc:MGI:1918367] |
| Ensembl ID | ENSMUSG00000026439 |
| Bio databases IDs | |
| Aliases | retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit |
| Synonyms | 4933411J24Rik, C330016J05, RB binding protein 5, histone lysine methyltransferase complex subunit, RBQ3, retinoblastoma binding protein 5, histone lysine methyltransferase complex subunit, SWD1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rbbp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone binding
- transcription regulator
- WD40 repeats
- double-stranded DNA binding
- nucleic acid binding
- WD domain, G-beta repeat
- WD40
- protein binding
- sequence-specific DNA binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- metabolic syndrome X
- migraines
role in cell
- expression in
- migration
- degradation in
- accumulation in
- DNA damage response
- transactivation in
- cell-matrix adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rbbp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to estrogen stimulus
- positive regulation of gene expression, epigenetic
- response to DNA damage stimulus
Cellular Component
Where in the cell the gene product is active
- Set1C/COMPASS complex
- nucleus
- histone methyltransferase complex
- nucleolus
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- histone binding
- transcription regulatory region sequence-specific DNA binding