Pfkfb3 Gene Summary [Mouse]
Predicted to enable 6-phosphofructo-2-kinase activity and fructose-2,6-bisphosphate 2-phosphatase activity. Acts upstream of or within several processes, including glial cell differentiation; glycolytic process; and motor behavior. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; integumental system; nervous system; sensory organ; and skeleton. Used to study extrinsic cardiomyopathy. Orthologous to human PFKFB3 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pfkfb3 |
| Official Name | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 [Source:MGI Symbol;Acc:MGI:2181202] |
| Ensembl ID | ENSMUSG00000026773 |
| Bio databases IDs | |
| Aliases | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 |
| Synonyms | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3, E330010H22Rik, IPFK2, PFK-2, PFKB3, Phosphofructokinase-2, uPFK-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pfkfb3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NK
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- fructose-2,6-bisphosphate 2-phosphatase
- nuclear localization sequence
- enzyme
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- 6-phosphofructo-2-kinase
Pathways
Biological processes and signaling networks where the Pfkfb3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- septic shock
- sepsis
- liver cancer
- epithelial cancer
- pulmonary hypertension
- organismal death
- weight loss
- insulin resistance
- primary pulmonary hypertension
role in cell
- phosphorylation in
- S phase
- expression in
- incorporation in
- apoptosis
- proliferation
- production in
- cell death
- growth
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pfkfb3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fructose 2,6-bisphosphate metabolic process
- fructose metabolic process
- carbohydrate phosphorylation
Cellular Component
Where in the cell the gene product is active
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- fructose-2,6-bisphosphate 2-phosphatase activity
- 6-phosphofructo-2-kinase activity