Tfb2m Gene Summary [Mouse]
Predicted to enable mitochondrial transcription factor activity and rRNA (adenine-N6,N6-)-dimethyltransferase activity. Predicted to be involved in rRNA methylation and transcription initiation at mitochondrial promoter. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and limb. Orthologous to human TFB2M (transcription factor B2, mitochondrial). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Tfb2m |
| Official Name | transcription factor B2, mitochondrial [Source:MGI Symbol;Acc:MGI:107937] |
| Ensembl ID | ENSMUSG00000026492 |
| Bio databases IDs | |
| Aliases | transcription factor B2, mitochondrial |
| Synonyms | Hkp1, h-mtTFB, h-mtTFB2, hTFB2M, LOC108348143, mTFB2M, mtTFB2, transcription factor B2, mitochondrial |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tfb2m often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ribosomal RNA small subunit methyltransferase A
- Ribosomal RNA adenine dimethylase
- enzyme
- AdoMet_MTases
Pathways
Biological processes and signaling networks where the Tfb2m gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial nucleoids
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tfb2m gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from mitochondrial promoter
- transcription initiation from mitochondrial promoter
- rRNA methylation
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
- mitochondrion
- mitochondrial nucleoid
Molecular Function
What the gene product does at the molecular level
- RNA binding
- mitochondrial RNA polymerase binding promoter specificity activity
- rRNA (adenine-N6,N6-)-dimethyltransferase activity