Sp4 Gene Summary [Mouse]
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Acts upstream of or within regulation of heart contraction. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Used to study schizophrenia. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Orthologous to human SP4 (Sp4 transcription factor). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sp4 |
| Official Name | trans-acting transcription factor 4 [Source:MGI Symbol;Acc:MGI:107595] |
| Ensembl ID | ENSMUSG00000025323 |
| Bio databases IDs | |
| Aliases | trans-acting transcription factor 4 |
| Synonyms | 5730497N03RIK, HF-1b, Sp4 transcription factor, SPR-1, trans-acting transcription factor 4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sp4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- zinc finger DNA binding domain
- transcription regulator
- protein binding
- sequence-specific DNA binding
- identical protein binding
- C2H2-type zinc finger
- DNA binding
- RNA polymerase II transcription factor activity, sequence-specific DNA binding
- zinc finger
- Zinc-finger double domain
- zinc finger domain
- N-terminal domain of transcription factor Specificity Proteins (SP) 1-4
- transcription factor activity
Pathways
Biological processes and signaling networks where the Sp4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insomnia
- metastasis
- major depression
- schizophrenia
- bipolar disorder
- acute lymphoblastic leukemia
- post-traumatic stress disorder
- spontaneous ventricular tachycardia
- neuroticism
- weight gain
role in cell
- transactivation in
- expression in
- quantity
- activation in
- branching
- signaling in
- remodeling
- pruning
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- soluble fraction
- chromatin fraction
- nuclear matrix fraction
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sp4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- cytosol
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity