Klrc1 Gene Summary [Mouse]
Predicted to enable HLA-E specific inhibitory MHC class Ib receptor activity and MHC class I protein complex binding activity. Predicted to be involved in positive regulation of natural killer cell mediated cytotoxicity and stimulatory C-type lectin receptor signaling pathway. Located in external side of plasma membrane. Is expressed in liver. Orthologous to several human genes including KLRC1 (killer cell lectin like receptor C1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Klrc1 |
| Official Name | killer cell lectin-like receptor subfamily C, member 1 [Source:MGI Symbol;Acc:MGI:1336161] |
| Ensembl ID | ENSMUSG00000030167 |
| Bio databases IDs | |
| Aliases | killer cell lectin-like receptor subfamily C, member 1 |
| Synonyms | CD159a, killer cell lectin-like receptor subfamily C, member 1, NKG2A, NKG2B |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Klrc1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- signaling receptor activity
- binding protein
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Lectin C-type domain
- transmembrane receptor
Pathways
Biological processes and signaling networks where the Klrc1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- plasma membrane extracellular face