Xcl1 Gene Summary [Mouse]

Enables chemokine activity. Involved in several processes, including mature natural killer cell chemotaxis; positive regulation of leukocyte migration; and positive regulation of production of molecular mediator of immune response. Acts upstream of or within chemotaxis and establishment of localization in cell. Located in extracellular space. Orthologous to several human genes including XCL1 (X-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Jul 2025]

Details

Type
Protein Coding
Official Symbol
Xcl1
Official Name
chemokine (C motif) ligand 1 [Source:MGI Symbol;Acc:MGI:104593]
Ensembl ID
ENSMUSG00000026573
Bio databases IDs NCBI: 16963 Ensembl: ENSMUSG00000026573
Aliases chemokine (C motif) ligand 1
Synonyms ATAC, chemokine (C motif) ligand 1, Lptn, LTN, Lymphotactin, SCM-1, SCM-1a, Scyc1, X-C motif chemokine ligand 1
Species
Mouse, Mus musculus
OrthologiesRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Xcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • chemokine
  • Small cytokines (intecrine/chemokine), interleukin-8 like
  • chemokine receptor binding
  • protein homodimerization
  • cytokine

Pathways

Biological processes and signaling networks where the Xcl1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • pancreatic ductal adenocarcinoma
  • pancreatic epithelial cancer
  • ductal pancreatic cancer
  • diabetic nephropathy
  • insulin-dependent diabetes mellitus
  • Sjögren syndrome
  • antibody-induced arthritis
regulated by
regulates
role in cell
  • proliferation
  • number
  • chemotaxis
  • cellular infiltration by
  • response by
  • cytolysis by
  • chemotaxis by
  • chemoattraction

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Extracellular Space

Gene-Specific Assays for Results You Can Trust

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