Xcl1

Predicted to enable CCR chemokine receptor binding activity; chemokine activity; and protein homodimerization activity. Predicted to be involved in several processes, including positive regulation of leukocyte migration; regulation of alpha-beta T cell activation; and regulation of gene expression. Predicted to act upstream of or within chemotaxis; establishment of localization in cell; and release of sequestered calcium ion into cytosol. Predicted to be active in extracellular space. Biomarker of anti-basement membrane glomerulonephritis. Orthologous to several human genes including XCL1 (X-C motif chemokine ligand 1). [provided by Alliance of Genome Resources, Apr 2025]

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Xcl1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.

Biological processes and signaling networks where the Xcl1 gene in rat plays a role, providing insight into its function and relevance in health or disease.

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.