Shcbp1 Gene Summary [Mouse]
Enables SH2 domain binding activity. Involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm; midbody; and spindle. Is expressed in forebrain; forelimb bud; midbrain ventricular layer; nephrogenic zone; and submandibular gland primordium. Orthologous to human SHCBP1 (SHC binding and spindle associated 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Shcbp1 |
| Official Name | Shc SH2-domain binding protein 1 [Source:MGI Symbol;Acc:MGI:1338802] |
| Ensembl ID | ENSMUSG00000022322 |
| Bio databases IDs | |
| Aliases | Shc SH2-domain binding protein 1 |
| Synonyms | LOC687121, mPAL, PAL, SHC binding and spindle associated 1, Shc SH2-domain binding protein 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Shcbp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Right handed beta helix region
- SH2-domain binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- bladder cancer
- organismal death
- experimental autoimmune encephalomyelitis
- HER2 negative hormone receptor negative breast cancer
- ulcerative colitis
- synovial sarcoma
- soft tissue sarcoma cancer
- MYC mutation positive B-cell lymphoma
role in cell
- expression in
- proliferation
- phosphorylation in
- colony formation
- number
- migration
- invasion by
- formation by
- G1/S phase transition
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Shcbp1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast growth factor receptor signaling pathway
- regulation of neural precursor cell proliferation
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- spindle
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH2 domain binding