Rab31 Gene Summary [Mouse]
Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Involved in positive regulation of phagocytosis, engulfment. Located in early phagosome membrane and phagocytic cup. Is expressed in axial musculature; nervous system; submandibular gland primordium; and vibrissa. Orthologous to human RAB31 (RAB31, member RAS oncogene family). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rab31 |
| Official Name | RAB31, member RAS oncogene family [Source:MGI Symbol;Acc:MGI:1914603] |
| Ensembl ID | ENSMUSG00000056515 |
| Bio databases IDs | |
| Aliases | RAB31, member RAS oncogene family |
| Synonyms | 1700093E07RIK, RAB0, Rab22B, RAB31, member RAS oncogene family |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rab31 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Small GTPase of the Ras superfamily (ill-defined subfamily)
- Ras family
- GTPase
- enzyme
- protein binding
- Ras subfamily of RAS small GTPases
- GTP binding
- small GTP-binding protein domain
- GDP binding
- Rab subfamily of small GTPases
- Ras of Complex, Roc, domain of DAPkinase
- Rho (Ras homology) subfamily of Ras-like small GTPases
- Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- metastasis
- gastric cancer
- systemic lupus erythematosus
- Dupuytren contracture
- Alzheimer disease
- lung adenocarcinoma
- lung adenocarcinoma formation
- severe acute respiratory syndrome
- organismal death
role in cell
- expression in
- proliferation
- apoptosis
- colony formation by
- activation in
- migration
- formation
- cisplatin sensitivity
- invasion by
- phagocytosis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- intracellular membrane-bounded organelle
- perinuclear region
- Nucleus
- Plasma Membrane
- vesicles
- Golgi Apparatus
- secretory granule membrane
- cytosol
- trans Golgi network
- endosomal membrane
- early endosomes
- late endosomes
- perinuclear vesicles
- phagosomes
- cis Golgi cisternae
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rab31 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to insulin stimulus
- positive regulation of phagocytosis, engulfment
- regulated secretory pathway
- Golgi to plasma membrane protein transport
- phagosome maturation
- intracellular protein transport
- receptor internalization
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- secretory granule membrane
- early endosome
- early phagosome membrane
- phagocytic vesicle
- cytosol
- endomembrane system
- phagocytic cup
- plasma membrane
- trans-Golgi network membrane
Molecular Function
What the gene product does at the molecular level
- GTP binding
- protein binding
- GTPase activity
- GDP binding