Ifna4 Gene Summary [Mouse]
Predicted to enable cytokine activity and type I interferon receptor binding activity. Acts upstream of or within defense response to virus and natural killer cell activation involved in immune response. Located in extracellular space. Human ortholog(s) of this gene implicated in Crimean-Congo hemorrhagic fever; common cold; hepatitis B; liver disease (multiple); and sarcoidosis. Orthologous to several human genes including IFNA1 (interferon alpha 1); IFNA13 (interferon alpha 13); and IFNA14 (interferon alpha 14). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ifna4 |
| Official Name | interferon alpha 4 [Source:MGI Symbol;Acc:MGI:107664] |
| Ensembl ID | ENSMUSG00000070904 |
| Bio databases IDs | |
| Aliases | interferon alpha 4 |
| Synonyms | If1ai13, Ifa4, IFN Alpha4, IFNα4, interferon alpha 4, interferon α 4 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ifna4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- IFab
- cytokine
Pathways
Biological processes and signaling networks where the Ifna4 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- Activation of IRF by Cytosolic Pattern Recognition Receptors
- Glucocorticoid Receptor Signaling
- IL-12 Signaling and Production in Macrophages
- Neuroinflammation Signaling Pathway
- Retinoic acid Mediated Apoptosis Signaling
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of Lipids/Lipid Rafts in the Pathogenesis of Influenza
- Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses
- Role of PI3K/AKT Signaling in the Pathogenesis of Influenza
- Role of PKR in Interferon Induction and Antiviral Response
- Role of RIG1-like Receptors in Antiviral Innate Immunity
- Role of WNT/GSK-3β Signaling in the Pathogenesis of Influenza
- Systemic Lupus Erythematosus Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cytopathic effect
role in cell
- phosphorylation in
- expression in
- proliferation
- growth
- molecular cleavage in
- signaling in
- replication in
- contact growth inhibition
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space