Kifap3 Gene Summary [Mouse]
The protein encoded by this gene is the non-motor subunit of kinesin-2 complex, and forms a heterotrimer with two members of the kinesin superfamily of proteins that together form a microtubule plus-end directed translocator that plays an important role in intracellular transport, mitosis, and cell-cell adhesion. This protein contains multiple armadillo repeats involved in protein binding, and may serve as an adaptor to regulate binding of cargo with the motor proteins. Conditional disruption of this gene in mouse neural precursor cells caused a tumor-like phenotype and defective organization of the neuroepithelium thought to be the result of altered N-cadherin subcellular localization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Details
| Type | Protein Coding |
| Official Symbol | Kifap3 |
| Official Name | kinesin-associated protein 3 [Source:MGI Symbol;Acc:MGI:107566] |
| Ensembl ID | ENSMUSG00000026585 |
| Bio databases IDs | |
| Aliases | kinesin-associated protein 3 |
| Synonyms | dJ190I16.1, FLA3, KAP-1, KAP-3, Kap3a, Kifap3 predicted, kinesin-associated protein 3, SMAP, Smg-GDS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Kifap3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Kinesin-associated protein (KAP)
- binding protein
- protein phosphatase binding
- protein binding
- kinesin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- heart failure
- amyotrophic lateral sclerosis
- anterior uveitis
- venous thromboembolism
- side effect
role in cell
- apoptosis
- transformation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- microtubule cytoskeleton
- ciliary tip
- cilia
- postsynaptic region
- cellular membrane
- filamentous network
- Plasma Membrane
- basal bodies
- vesicles
- centrosome
- Golgi Apparatus
- Endoplasmic Reticulum
- axonemes
- cytosol
- connecting cilia
- chromosome
- spindle fibers
- photoreceptor outer segments
- photoreceptor inner segments
- rod outer segments
- rod inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Kifap3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- macromolecular complex assembly
- signal transduction
- protein localization
- positive regulation of calcium-dependent cell-cell adhesion
- microtubule-based movement
- microtubule-based process
- plus-end-directed vesicle transport along microtubule
- neuroblast proliferation
- negative regulation of neuroblast proliferation
- cardiac muscle cell apoptotic process
- negative regulation of thymocyte apoptotic process
- thymocyte apoptotic process
- negative regulation of cardiac muscle cell apoptotic process
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- microtubule cytoskeleton
- cilium basal body
- kinesin II complex
- endoplasmic reticulum
- Golgi apparatus
- axoneme
- condensed nuclear chromosome
- photoreceptor outer segment
- spindle microtubule
- centrosome
- cilium
- cytosol
- ciliary transition zone
- photoreceptor inner segment
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein phosphatase binding
- kinesin binding