Ncf2 Gene Summary [Mouse]
Enables small GTPase binding activity. Contributes to superoxide-generating NAD(P)H oxidase activity. Acts upstream of or within superoxide anion generation. Located in acrosomal vesicle. Is expressed in several structures, including hemolymphoid system; limb; and liver. Human ortholog(s) of this gene implicated in Alzheimer's disease; autosomal recessive chronic granulomatous disease 2; and rheumatoid arthritis. Orthologous to human NCF2 (neutrophil cytosolic factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ncf2 |
| Official Name | neutrophil cytosolic factor 2 [Source:MGI Symbol;Acc:MGI:97284] |
| Ensembl ID | ENSMUSG00000026480 |
| Bio databases IDs | |
| Aliases | neutrophil cytosolic factor 2 |
| Synonyms | NADPH OXIDASE, neutrophil cytosolic factor 2, NOXA2, NSF2, P67-PHOX |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ncf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- electron carrier
- activation domain
- superoxide-generating NADPH oxidase activator
- Rac effector domain
- enzyme binding
- enzyme
- protein binding
- PB1
- superoxide-generating NADPH oxidase
- Phox and Bem1 domain
- Src Homology 3 domain superfamily
- Tetratricopeptide repeats
- PR domain
- tetratricopeptide repeat
Pathways
Biological processes and signaling networks where the Ncf2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- myocardial infarction
- metastasis
- chronic granulomatous disease
- systemic lupus erythematosus
- cytochrome b-positive autosomal recessive chronic granulomatous disease type 2
- Alzheimer disease
- androgenic alopecia
- diabetes mellitus
- rheumatoid arthritis
- HER2 negative hormone receptor negative breast cancer
role in cell
- phosphorylation in
- proliferation
- apoptosis
- cell death
- expression in
- activation in
- survival
- migration
- production in
- formation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- high-density microsomal fractions
- raft fractions
- membrane fraction
- cytoskeleton
- cellular membrane
- Plasma Membrane
- phagolysosome
- Mitochondria
- cytosol
- acrosome
- synapse
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ncf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular defense response
- superoxide metabolic process
- innate immune response
- phagocytosis
- respiratory burst
- superoxide anion generation
Cellular Component
Where in the cell the gene product is active
- NADPH oxidase complex
- phagolysosome
- acrosomal vesicle
- membrane
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- electron carrier activity
- superoxide-generating NADPH oxidase activity
- superoxide-generating NADPH oxidase activator activity
- small GTPase binding