Spopl Gene Summary [Mouse]
Predicted to enable identical protein binding activity and ubiquitin protein ligase binding activity. Predicted to be involved in negative regulation of protein ubiquitination; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of proteolysis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system and genitourinary system. Orthologous to human SPOPL (speckle type BTB/POZ protein like). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spopl |
| Official Name | speckle-type BTB/POZ protein-like [Source:MGI Symbol;Acc:MGI:1924107] |
| Ensembl ID | ENSMUSG00000026771 |
| Bio databases IDs | |
| Aliases | speckle-type BTB/POZ protein-like |
| Synonyms | 4921517N04Rik, AU014935, BB233739, BTBD33, E430033K04Rik, RGD1305847, speckle-type BTB/POZ protein-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spopl often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MATH
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spopl gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of proteolysis
- negative regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ubiquitin protein ligase binding
- protein binding