Homer3 Gene Summary [Mouse]
Enables protein domain specific binding activity. Involved in regulation of postsynaptic neurotransmitter receptor activity. Located in basal part of cell and cytosol. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including exocrine system; jaw; nervous system; sensory organ; and tongue. Orthologous to human HOMER3 (homer scaffold protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Homer3 |
| Official Name | homer scaffolding protein 3 [Source:MGI Symbol;Acc:MGI:1347359] |
| Ensembl ID | ENSMUSG00000003573 |
| Bio databases IDs | |
| Aliases | homer scaffolding protein 3 |
| Synonyms | Homer, homer scaffolding protein 3, homer scaffold protein 3, VESL3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Homer3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- coiled-coil domain
- protein domain specific binding
- leucine zipper domain
- EVH1 domain
- protein binding
- Pleckstrin homology-like domain
- identical protein binding
Pathways
Biological processes and signaling networks where the Homer3 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- organismal death
- touch abnormality
- non-small cell lung cancer
- mitochondrial disorder
role in cell
- apoptosis
- invasion by
- proliferation
- migration
- chemotaxis
- calcium oscillation
- dynamics in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- microsomal fraction
- nuclear fraction
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- Cytoplasm
- basal compartment
- immunological synapses
- cytosol
- dendritic spines
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Homer3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting
- negative regulation of interleukin-2 production
- negative regulation of calcineurin-NFAT signaling cascade
- G-protein coupled glutamate receptor signaling pathway
- regulation of store-operated calcium entry
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- basal part of cell
- cytoplasm
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- identical protein binding
- protein binding
- G-protein coupled glutamate receptor binding