SPOPL Gene Summary [Human]
Predicted to enable ubiquitin protein ligase binding activity. Involved in negative regulation of protein ubiquitination and proteasome-mediated ubiquitin-dependent protein catabolic process. Part of Cul3-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SPOPL |
| Official Name | speckle type BTB/POZ protein like [Source:HGNC Symbol;Acc:HGNC:27934] |
| Ensembl ID | ENSG00000144228 |
| Bio databases IDs | |
| Aliases | speckle type BTB/POZ protein like, HIB homolog 2, roadkill homolog 2 |
| Synonyms | 4921517N04Rik, AU014935, BB233739, BTBD33, E430033K04Rik, RGD1305847, speckle-type BTB/POZ protein-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SPOPL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MATH
- Broad-Complex, Tramtrack and Bric a brac
- BTB_POZ
- BTB/POZ domain
- protein binding
- BACK (BTB and C-terminal Kelch) domain
- identical protein binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Unknown
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SPOPL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- regulation of proteolysis
- negative regulation of protein ubiquitination
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- Cul3-RING ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- ubiquitin protein ligase binding
- protein binding