St6galnac6 Gene Summary [Mouse]
Enables alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity. Involved in oligosaccharide biosynthetic process. Acts upstream of or within ganglioside biosynthetic process. Located in cytoplasm. Is expressed in alimentary system; axial muscle; brain; craniocervical region bone; and exocrine system. Orthologous to human ST6GALNAC6 (ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | St6galnac6 |
| Official Name | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 [Source:MGI Symbol;Acc:MGI:1355316] |
| Ensembl ID | ENSMUSG00000026811 |
| Bio databases IDs | |
| Aliases | ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 |
| Synonyms | SIAT7-F, ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, ST6GALNACVI, ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, ST6 N-acetylgalactosaminide α-2,6-sialyltransferase 6, ST6 (α-N-acetyl-neuraminyl-2,3-β-galactosyl-1,3)-N-acetylgalactosaminide α-2,6-sialyltransferase 6 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse St6galnac6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Glycosyltransferase family 29 (sialyltransferase)
- glycosyltransferase family 29
- sialyltransferase
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
regulates
- SELE
- ganglioside GT1
- oligosaccharide
- disialosylglobopentaosylceramide
- 2->3,2->6 disialyl Lewis(A)
- SIGLEC7
- sialyl-lactotetraosylceramide
- ganglioside GD1a
- glycosphingolipid
- glycoprotein
role in cell
- synthesis in
- binding
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- cellular membrane
- Golgi membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse St6galnac6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glycoprotein metabolic process
- protein glycosylation
- oligosaccharide biosynthetic process
- oligosaccharide metabolic process
- glycosylceramide metabolic process
- glycosphingolipid biosynthetic process
- cell-cell recognition
- glycosphingolipid metabolic process
- ganglioside biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- membrane
- Golgi membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
- protein binding
- sialyltransferase activity