Sprr1a Gene Summary [Mouse]
Predicted to be a structural constituent of skin epidermis. Predicted to be involved in keratinocyte differentiation and peptide cross-linking. Located in cell periphery. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and nose. Orthologous to human SPRR1A (small proline rich protein 1A). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sprr1a |
| Official Name | small proline-rich protein 1A [Source:MGI Symbol;Acc:MGI:106660] |
| Ensembl ID | ENSMUSG00000050359 |
| Bio databases IDs | |
| Aliases | small proline-rich protein 1A |
| Synonyms | mSPRR1A, small proline-rich protein 1A, Spr, SPR1a, Sprr, Sprr1, Sprr1al, Sprr1b |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sprr1a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cornifin (SPRR) family
- structural constituent of epidermis
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cornified envelope
- cell periphery