Pmpca Gene Summary [Mouse]
Predicted to enable endopeptidase activity. Predicted to contribute to metallopeptidase activity. Predicted to be involved in protein processing involved in protein targeting to mitochondrion. Located in mitochondrion. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 2. Orthologous to human PMPCA (peptidase, mitochondrial processing subunit alpha). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pmpca |
| Official Name | peptidase (mitochondrial processing) alpha [Source:MGI Symbol;Acc:MGI:1918568] |
| Ensembl ID | ENSMUSG00000026926 |
| Bio databases IDs | |
| Aliases | peptidase (mitochondrial processing) alpha |
| Synonyms | 1200002L24Rik, 4933435E07RIK, Alpha-MPP, CLA1, CPD3, INPP5E, KIAA0123, MAS2, MITOCHONDRIAL PROCESSING PEPTIDASE A, MITOCHONDRIAL PROCESSING PROTEASE, MPPA, P-55, peptidase (mitochondrial processing) alpha, peptidase, mitochondrial processing subunit alpha, peptidase, mitochondrial processing subunit α, peptidase (mitochondrial processing) α, SCAR2, α-MPP |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pmpca often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- metallopeptidase
- endopeptidase
- peptidase
- mitochondrial processing peptidase
- protein binding
- Insulinase (Peptidase family M16)
- Peptidase M16 inactive domain
Pathways
Biological processes and signaling networks where the Pmpca gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial matrix
- mitochondrial inner membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pmpca gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein processing involved in protein targeting to mitochondrion
Cellular Component
Where in the cell the gene product is active
- extracellular space
- mitochondrion
- mitochondrial processing peptidase complex
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- metalloendopeptidase activity