Mrpl44 Gene Summary [Mouse]
Predicted to enable double-stranded RNA binding activity and ribonuclease III activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion; nuclear body; and plasma membrane. Predicted to be part of mitochondrial large ribosomal subunit. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; sensory organ; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 16. Orthologous to human MRPL44 (mitochondrial ribosomal protein L44). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mrpl44 |
| Official Name | mitochondrial ribosomal protein L44 [Source:MGI Symbol;Acc:MGI:1916413] |
| Ensembl ID | ENSMUSG00000026248 |
| Bio databases IDs | |
| Aliases | mitochondrial ribosomal protein L44 |
| Synonyms | 1810030E18Rik, 5730593H20Rik, COXPD16, L44MT, mitochondrial ribosomal protein L44, mL44 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mrpl44 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded RNA binding motif (DSRM) superfamily
- enzyme
- protein binding
- RIBOc
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- combined oxidative phosphorylation deficiency 16
- insulin resistance
- global developmental delay
- infantile hypertrophic cardiomyopathy
- hepatoencephalopathy due to combined oxidative phosphorylation defect type 1
- mitochondrial disorder
- productive infection by HIV-1
role in cell
- elongation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- Plasma Membrane
- Mitochondria
- mitochondrial inner membrane
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mrpl44 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitochondrial translation
- RNA processing
- mitochondrial translational elongation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- mitochondrion
- mitochondrial large ribosomal subunit
- mitochondrial inner membrane
- plasma membrane
- microprocessor complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ribonuclease III activity
- protein binding
- RNA binding
- double-stranded RNA binding