Dync1i2 Gene Summary [Mouse]
Predicted to enable dynein heavy chain binding activity and dynein light chain binding activity. Predicted to be involved in negative regulation of neuron projection development and transport along microtubule. Part of outer dynein arm. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; limb bud; and nose. Orthologous to human DYNC1I2 (dynein cytoplasmic 1 intermediate chain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dync1i2 |
| Official Name | dynein cytoplasmic 1 intermediate chain 2 [Source:MGI Symbol;Acc:MGI:107750] |
| Ensembl ID | ENSMUSG00000027012 |
| Bio databases IDs | |
| Aliases | dynein cytoplasmic 1 intermediate chain 2 |
| Synonyms | 3110079H08Rik, DH IC-2, DIC74, DNCI2, DNCIC2, dynein cytoplasmic 1 intermediate chain 2, Dynein intermediate chain 2a, IC2, NEDMIBA |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dync1i2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- WD40 repeats
- WD domain, G-beta repeat
- WD40
- protein binding
- Cytoplasmic dynein 1 intermediate chain 2
Pathways
Biological processes and signaling networks where the Dync1i2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neurodevelopmental disorder with microcephaly, hypotonia and variable brain anomalies
- neurodevelopmental disorder with microcephaly and structural brain anomalies
role in cell
- localization
- movement by
- development
- movement
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- vesicles
- centrosome
- microtubules
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dync1i2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- microtubule-based transport
- microtubule-based movement
Cellular Component
Where in the cell the gene product is active
- cytoplasmic dynein complex
- centrosome
- cytoplasm
- dynein complex
- cytosol
- vesicle
- microtubule
Molecular Function
What the gene product does at the molecular level
- microtubule motor activity
- protein binding
- dynein heavy chain binding
- dynein light chain binding