Rnf2 Gene Summary [Mouse]
Enables chromatin binding activity and histone H2AK119 ubiquitin ligase activity. Involved in germ cell development and negative regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within with a negative effect on gene expression. Acts upstream of or within anterior/posterior axis specification; gastrulation with mouth forming second; and mitotic cell cycle. Located in euchromatin; nuclear body; and sex chromatin. Part of PRC1 complex. Is active in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early embryo; genitourinary system; limb; and retina. Human ortholog(s) of this gene implicated in Luo-Schoch-Yamamoto syndrome. Orthologous to human RNF2 (ring finger protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rnf2 |
| Official Name | ring finger protein 2 [Source:MGI Symbol;Acc:MGI:1101759] |
| Ensembl ID | ENSMUSG00000026484 |
| Bio databases IDs | |
| Aliases | ring finger protein 2 |
| Synonyms | BAP-1, DING, HIPI3, LUSYAM, RING1B, RING2, ring finger protein 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rnf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- nuclear localization sequence
- chromatin binding
- coiled-coil domain
- protein domain specific binding
- enzyme
- Ring finger domain
- protein binding
- zinc ion binding
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- RING-type zinc-finger
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- ubiquitin C-terminal hydrolase domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- liver cancer
- growth failure
- metastasis
- breast cancer
- survival
- gastrulation failure
- HER2 negative hormone receptor negative breast cancer
- Luo-Schoch-Yamamoto syndrome
role in cell
- expression in
- proliferation
- apoptosis
- degradation in
- survival
- signaling in
- ubiquitination in
- migration
- accumulation in
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- heterochromatin
- Cytoplasm
- centromeric region
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- sex chromatin
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rnf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- germ cell development
- negative regulation of transcription from RNA polymerase II promoter
- anterior/posterior axis specification
- chromatin remodeling
- gastrulation with mouth forming second
- gene expression
- negative regulation of sequence-specific DNA binding transcription factor activity
- regulation of gene expression, epigenetic
- mitotic cell cycle
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- euchromatin
- nuclear body
- PRC1 complex
- ubiquitin ligase complex
- cytoplasm
- PcG protein complex
- sex chromatin
- nucleoplasm
- MLL1 complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- protein binding
- RING-like zinc finger domain binding
- chromatin binding