Ect2 Gene Summary [Mouse]
Enables small GTPase binding activity. Involved in positive regulation of neuron differentiation and positive regulation of protein import into nucleus. Acts upstream of or within cell morphogenesis. Located in cytoplasm and nucleus. Is expressed in brain; liver; and neural retina. Orthologous to human ECT2 (epithelial cell transforming 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ect2 |
| Official Name | ect2 oncogene [Source:MGI Symbol;Acc:MGI:95281] |
| Ensembl ID | ENSMUSG00000027699 |
| Bio databases IDs | |
| Aliases | ect2 oncogene |
| Synonyms | ARHGEF31, ect2 oncogene, epithelial cell transforming 2, FLJ10461 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ect2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- BRCT
- catalytic domain
- twin BRCT domain
- nuclear localization sequence
- enzyme binding
- GTPase activator
- protein binding
- Pleckstrin homology-like domain
- RhoGEF domain
- RhoGEF
- guanyl-nucleotide exchange factor
- BRCA1 C Terminus (BRCT) domain
- protein homodimerization
- Dbl homology domain
- breast cancer carboxy-terminal domain
Pathways
Biological processes and signaling networks where the Ect2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- colorectal cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- lung squamous cell carcinoma
- lung cancer
- glioma formation
- squamous cell lung cancer
- non-small cell lung carcinoma
- lung adenocarcinoma
role in cell
- activation in
- apoptosis
- proliferation
- survival
- migration
- growth
- differentiation
- assembly
- attachment
- binucleation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- midbody
- intercellular junctions
- cytosol
- nucleoplasm
- nuclear bodies
- tight junctions
- cleavage furrow
- cellular protrusions
- central spindle
- mitotic spindle
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ect2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein import into nucleus
- regulation of protein kinase activity
- cell morphogenesis
- protein transport
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- nervous system development
- protein homooligomerization
- positive regulation of neuron differentiation
- positive regulation of GTPase activity
- cellular response to calcium ion
- regulation of small GTPase mediated signal transduction
- cytokinesis after mitosis
- positive regulation of apoptotic process
- tight junction assembly
- cell differentiation
- cellular response to ionizing radiation
- activation of protein kinase activity
- regulation of cytokinesis, actomyosin contractile ring assembly
- cellular response to hydrogen peroxide
- regulation of attachment of spindle microtubules to kinetochore
- intracellular signal transduction
- positive regulation of cytokinesis
Cellular Component
Where in the cell the gene product is active
- nuclear body
- cleavage furrow
- nucleoplasm
- nucleus
- tight junction
- centrosome
- cell-cell junction
- mitotic spindle
- cytoplasm
- cell cortex
- centralspindlin complex
- cytosol
- midbody
Molecular Function
What the gene product does at the molecular level
- protein binding
- protein homodimerization activity
- GTPase activator activity
- guanyl-nucleotide exchange factor activity
- small GTPase binding