Dhrs9 Gene Summary [Mouse]
Predicted to enable all-trans-retinol dehydrogenase (NAD+) activity and steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor. Predicted to be involved in 9-cis-retinoic acid biosynthetic process; androgen metabolic process; and progesterone metabolic process. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in intracellular membrane-bounded organelle. Orthologous to human DHRS9 (dehydrogenase/reductase 9). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dhrs9 |
| Official Name | dehydrogenase/reductase (SDR family) member 9 [Source:MGI Symbol;Acc:MGI:2442798] |
| Ensembl ID | ENSMUSG00000027068 |
| Bio databases IDs | |
| Aliases | dehydrogenase/reductase (SDR family) member 9 |
| Synonyms | 3ALPHA-HSD, 3-α-HSD, C730025I08Rik, dehydrogenase/reductase 9, Eroldh, hRoDH-E2, NOVEL type MICROSOMAL 3alpha-HSD, RDH15, RDHL, RDH-TBE, RETSDR8, SDR9C4, Similar to alcohol dehydrogenase pan1b-like |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dhrs9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NADP-retinol dehydrogenase
- alcohol dehydrogenase
- Rossmann-fold NAD(P)(+)-binding proteins
- 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD)
- 3alpha(or 20beta)-hydroxysteroid dehydrogenase
- retinol dehydrogenase
- 3(or 17)alpha-hydroxysteroid dehydrogenase
- enzyme
- protein binding
- Enoyl-(Acyl carrier protein) reductase
- short chain dehydrogenase
Pathways
Biological processes and signaling networks where the Dhrs9 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- atrial fibrillation
- diabetes mellitus
- dextran sodium sulfate-induced colitis
- systemic sclerosis
- polycystic kidney disease
- lung cancer
- systemic lupus erythematosus
- colorectal cancer
- diabetic nephropathy
regulates
- tretinoin
- vitamin A
- ATP5F1E
- androgen
- dihydrotestosterone
- 3-alpha,17-beta-androstanediol
- progesterone
- NDUFA3
- androsterone
- 20-alpha-hydroxyprogesterone
role in cell
- proliferation
- expression in
- colony formation by
- migration
- oxygen consumption rate
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- endoplasmic reticulum membrane
- microsomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dhrs9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- progesterone metabolic process
- androgen metabolic process
- 9-cis-retinoic acid biosynthetic process
- retinol metabolic process
- steroid metabolic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- intracellular membrane-bounded organelle
Molecular Function
What the gene product does at the molecular level
- racemase and epimerase activity
- androstan-3-alpha,17-beta-diol dehydrogenase activity
- retinol dehydrogenase activity
- testosterone dehydrogenase (NAD+) activity
- androsterone dehydrogenase activity
- alcohol dehydrogenase (NAD) activity