Slc2a8 Gene Summary [Mouse]
Enables D-glucose binding activity; dehydroascorbic acid transmembrane transporter activity; and hexose transmembrane transporter activity. Involved in D-glucose transmembrane transport; dehydroascorbic acid transport; and fructose transmembrane transport. Acts upstream of or within insulin receptor signaling pathway and response to hypoxia. Located in plasma membrane. Is expressed in several structures, including adipose tissue; gut; liver; placenta; and spleen. Orthologous to human SLC2A8 (solute carrier family 2 member 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Slc2a8 |
| Official Name | solute carrier family 2, (facilitated glucose transporter), member 8 [Source:MGI Symbol;Acc:MGI:1860103] |
| Ensembl ID | ENSMUSG00000026791 |
| Bio databases IDs | |
| Aliases | solute carrier family 2, (facilitated glucose transporter), member 8 |
| Synonyms | D2Ertd44e, GLUT8, GLUTX1, solute carrier family 2, (facilitated glucose transporter), member 8, solute carrier family 2 member 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slc2a8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hexose transporter
- benzoate transport
- Sugar (and other) transporter
- fructose uniporter
- MFS transporter, sugar porter (SP) family
- Major Facilitator Superfamily
- glucose binding
- galactose transporter
- organic anion transporter
- fructose transporter
- transporter
Pathways
Biological processes and signaling networks where the Slc2a8 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- streptozotocin induced type1 diabetes
- asthenozoospermia
- dilated cardiomyopathy
role in cell
- expression in
- growth
- proliferation
- function
- lipogenesis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endocytic vesicle membrane
- Cytoplasm
- intracellular space
- intracellular membranes
- cellular membrane
- vesicles
- synaptic vesicles
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slc2a8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- dehydroascorbic acid transport
- response to hypoxia
- insulin receptor signaling pathway
- hexose transport
- fructose transport
Cellular Component
Where in the cell the gene product is active
- clathrin-coated endocytic vesicle membrane
- membrane
- lysosomal membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- glucose binding
- D-glucose transmembrane transporter activity
- dehydroascorbic acid transporter activity
- fructose transmembrane transporter activity
- glucose transmembrane transporter activity